How Much Arimidex for 500mg Test?

If you’re running 500mg of testosterone per week, the question of how much Arimidex to take is probably already on your mind. Estrogen management isn’t optional at that dosage—it’s critical. Elevated estrogen can cause water retention, mood swings, and even gynecomastia if you’re prone to it. But the fix isn’t as simple as blasting Arimidex and calling it a day. Too much and you crash estrogen, which can wreck your joints, tank your mood, and actually hurt your results.

When we’re talking about testosterone use—whether it’s a prescribed medical protocol or someone exploring performance enhancement—it always comes back to balance. In a medical setting, Testosterone Replacement Therapy is dosed and monitored with labs to keep you in an optimized range. At 500mg per week, though, you’re outside therapeutic dosing and into supraphysiological levels. That means your aromatization rate (testosterone converting to estrogen) will be much higher than what most TRT patients experience.

The Reality of Arimidex Dosing at 500mg

There’s no universal “one-size-fits-all” answer. Your genetics, body fat percentage, and even diet impact how much testosterone converts to estrogen. That said, a common starting point for guys running 500mg of testosterone is around 0.25mg to 0.5mg of Arimidex every other day. Some need more, some less. The only way to know what’s right for you is by running bloodwork—not guessing.

Remember, Arimidex is powerful. More isn’t better. Crushing estrogen feels just as bad as having too much. The sweet spot is usually keeping estradiol in the mid-20s to 30s (pg/mL). That’s when most men feel strong, stable, and clear-headed.

Practical Tips You Won’t Hear Everywhere

• Start conservative. Begin with the lowest effective dose and adjust based on symptoms and labs.
• Don’t chase numbers blindly. High estrogen symptoms (puffiness, nipple sensitivity, mood swings) matter more than the raw lab value.
• Factor in your body comp. Higher body fat means more aromatase activity, so dosing needs may be higher.
• Labs are non-negotiable. Anyone telling you to dose Arimidex “by feel only” is setting you up for problems.

FAQ

How much Arimidex should I take if I’m on 500mg testosterone weekly?
Most start around 0.25–0.5mg every other day, but actual needs vary. Bloodwork is the only reliable way to dial it in.

Can I just take a full 1mg of Arimidex daily to be safe?
That’s usually too much. Daily 1mg dosing almost always crashes estrogen, which can feel worse than high estrogen.

What happens if I don’t use Arimidex at all on 500mg testosterone?
Some men tolerate it fine, but most will see estrogen-related side effects. The risk increases with body fat and the length of the cycle.

Is Arimidex safe long term?
Long-term use at improper doses can harm cholesterol levels and bone health. That’s why monitoring matters.

If you’re serious about optimizing hormones—whether you’re on therapeutic TRT or considering higher doses—the right guidance and monitoring make all the difference. At AlphaMD, our focus is helping men take control of their health with expert protocols, regular labs, and evidence-based support.