question from a user
In an earlier comment you stated that 0.25mg of anastrozole will lower E2 by an average of 7.5 pg/mL. How much could you reasonably expect 6.5mg/12.5mg of aromasin would lower E2?
AlphaMD's Answer
Exemestane (aromasin) is much stronger than anastrozole in that it completely eradicates aromatase. In studies, a single dose of 25mg of exemestane lowered estradiol by 98%. Following that logic, a 12.5mg dose would be expected to lower estrogen by around ~49% and 6.25mg would be expected to lower it by ~24%. The half life of the medicine is 24 hours, so twice weekly dosing is typical.
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