Enclomiphene Treatment

Enclomiphene is an oral prescription treatment that a licensed clinician may consider for eligible men seeking to support natural testosterone production without directly replacing testosterone.

Rather than supplying the body with external testosterone, enclomiphene may stimulate hormonal signals involved in testosterone and sperm production. This may make it an option for certain men with low testosterone who want to maintain testicular function or help maintain sperm production.

Starting at $129 per month

What Is Enclomiphene?

Enclomiphene is an oral selective estrogen receptor modulator, commonly called a SERM. It is one of the two primary isomers found in clomiphene citrate.

In eligible men, enclomiphene may increase the release of:

• Luteinizing hormone, or LH, which signals the testes to produce testosterone
• Follicle-stimulating hormone, or FSH, which supports sperm production

Unlike testosterone replacement therapy, enclomiphene does not directly supply the body with testosterone. Instead, it works through the body’s existing hormone-signaling system.

Enclomiphene is not currently FDA-approved as a standalone medication. When prescribed, patients should receive information about its regulatory status, potential benefits, limitations, risks, and available treatment alternatives.

Potential Benefits of Enclomiphene

Results vary, and potential benefits depend on the cause of low testosterone, baseline hormone levels, treatment response, and overall health.

Supports Natural Testosterone Production

May stimulate the hormonal pathway that signals the testes to produce testosterone.

May Increase Total Testosterone

May help raise testosterone levels in eligible men with certain forms of secondary hypogonadism.

Supports LH and FSH Production

May increase the hormones involved in natural testosterone and sperm production.

May Help Maintain Sperm Production

Enclomiphene may be less likely than traditional testosterone replacement therapy to suppress sperm production.

Supports Testicular Function

Works through the body’s existing hormone-production system rather than replacing testosterone directly.

Convenient Oral Treatment

Taken by mouth without:

• Injections
• Gels
• Creams
• Patches
• Pellets

May Support Energy and Motivation

Some men whose symptoms are associated with low testosterone may notice improvements as hormone levels change.

May Support Libido and Sexual Wellness

Addressing low testosterone may support sexual desire and overall sexual well-being in some patients.

May Support Mood and Mental Clarity

Some patients may experience changes in mood, focus, or general well-being during treatment.

May Be an Alternative to Traditional TRT

A licensed clinician may consider enclomiphene for certain men who want to stimulate natural testosterone production rather than begin direct testosterone replacement.

How Does Enclomiphene Work?

Testosterone production is regulated by the hypothalamic-pituitary-gonadal axis.

The process generally works as follows:

1. The hypothalamus releases gonadotropin-releasing hormone, or GnRH.
2. GnRH signals the pituitary gland to release LH and FSH.
3. LH signals the testes to produce testosterone.
4. FSH helps support sperm production.

Enclomiphene reduces some of the estrogen feedback received by the hypothalamus and pituitary gland. This may cause the body to release more LH and FSH, encouraging the testes to produce more testosterone.

This differs from testosterone replacement therapy, which supplies testosterone from an outside source and can reduce the body’s production of:

• LH
• FSH
• Testosterone
• Sperm

Enclomiphene vs. Testosterone Replacement Therapy

Enclomiphene and testosterone replacement therapy may both be considered when addressing low testosterone, but they work differently.

Enclomiphene

• Encourages natural testosterone production
• May increase LH and FSH
• Is taken orally
• May help maintain sperm production
• Requires functioning testicular tissue
• May be considered for certain forms of secondary or functional hypogonadism

Testosterone Replacement Therapy

• Supplies testosterone directly
• Commonly lowers LH and FSH
• Is available as injections, creams, gels, patches, pellets, and other formulations
• Can suppress sperm production
• May be appropriate when the testes cannot produce sufficient testosterone
• May provide a more direct increase in testosterone levels

Neither option is automatically appropriate for every patient. A licensed clinician will consider symptoms, laboratory results, medical history, fertility goals, treatment preferences, and clinical needs before recommending treatment.

Who May Be a Candidate for Enclomiphene?

A licensed clinician may consider enclomiphene for adult men who:

• Have symptoms associated with low testosterone
• Have low testosterone confirmed through appropriate laboratory testing
• Have low or inappropriately normal LH and FSH levels
• May have secondary or functional hypogonadism
• Want to support natural testosterone production
• Prefer an oral treatment over injections or topical testosterone
• Are concerned about maintaining sperm production
• May want to have children in the future
• Have functioning testes that may respond to hormonal stimulation
• Are medically appropriate for treatment following a clinical evaluation

Eligibility cannot be determined by symptoms alone. Laboratory testing and an evaluation by a licensed clinician are required.

Who May Not Be a Good Candidate?

Enclomiphene may not be appropriate for men who:

• Have primary testicular failure
• Already have significantly elevated LH or FSH levels
• Have certain pituitary or hypothalamic conditions requiring further evaluation
• Have unexplained visual symptoms
• Have experienced a serious reaction to clomiphene or a related medication
• Have uncontrolled or untreated medical conditions
• Take medications that may interact with treatment
• Have certain hormone-sensitive medical conditions
• Do not have confirmed low testosterone
• Have symptoms that require urgent or specialist evaluation

A licensed clinician will review your health history, medications, symptoms, laboratory results, and treatment goals before determining whether enclomiphene is medically appropriate.

Enclomiphene Dosage

Enclomiphene dosing is individualized according to baseline hormone levels, symptoms, treatment response, tolerance, and follow-up laboratory results.

A clinician-directed treatment plan may include:

• Typical starting dosage: 12.5 mg orally every other day
• Adjusted dosage: A licensed clinician may adjust the dosage to between 25 mg and 50 mg orally once daily when medically appropriate

The prescribed dosage may depend on:

• Total and free testosterone levels
• LH and FSH levels
• Estradiol levels
• Symptoms and treatment goals
• Response to treatment
• Potential side effects
• Other medical conditions and medications

Take enclomiphene only as prescribed. Do not increase, decrease, or stop your medication without speaking with the licensed clinician overseeing your care.

What Results Can You Expect?

Hormone levels may begin changing within the first several weeks, but the timing and degree of response vary from patient to patient.

The licensed clinician overseeing your care may monitor:

• Total testosterone
• Free testosterone
• Luteinizing hormone
• Follicle-stimulating hormone
• Estradiol
• Sex hormone-binding globulin
• Complete blood count
• Liver or metabolic markers when appropriate
• Symptoms and treatment tolerance
• Semen parameters when fertility is an active concern

An increase in testosterone on laboratory testing does not guarantee that every symptom will improve.

Symptoms such as the following may have multiple causes:

• Fatigue
• Reduced libido
• Erectile concerns
• Mood changes
• Weight gain
• Sleep problems
• Difficulty concentrating

Follow-up testing helps the clinician overseeing your care determine whether treatment is producing an appropriate hormonal and clinical response.

Enclomiphene Side Effects

Enclomiphene is generally tolerated by many patients, but side effects can occur. The licensed clinician overseeing your care may monitor symptoms, hormone levels, and treatment response to help identify potential concerns.

Commonly Reported Side Effects

Possible side effects may include:

• Headache
• Dizziness
• Nausea
• Abdominal discomfort
• Fatigue
• Mood changes
• Irritability
• Changes in libido
• Acne or oily skin
• Sleep changes
• Breast tenderness
• Increased estradiol levels

Hormonal Changes

Because enclomiphene stimulates natural testosterone production, it may affect other hormone levels.

Potential changes may include:

• Increased testosterone
• Increased LH
• Increased FSH
• Increased estradiol
• Changes in libido, mood, or energy

Follow-up laboratory testing helps the clinician overseeing your care determine whether your dosage remains appropriate.

Vision-Related Symptoms

Visual side effects appear to be uncommon, but patients should promptly report:

• Blurred vision
• Flashing lights
• Spots or floaters
• Increased sensitivity to light
• Other new or persistent changes in vision

When to Seek Medical Attention

Contact the clinician overseeing your care if side effects are persistent, worsening, or interfering with daily life.

Seek urgent medical attention for:

• Severe or sudden vision changes
• Chest pain
• Difficulty breathing
• Fainting
• Severe headache
• Signs of a serious allergic reaction
• Other sudden or concerning symptoms

This is not a complete list of possible side effects. Enclomiphene should only be used under the supervision of a licensed medical clinician.

Enclomiphene Pricing

Starting at $129 per Month*

• 3-Month Commitment: $159 per month
• 6-Month Commitment: $139 per month
• 12-Month Commitment: $129 per month

*Pricing applies to the applicable program and commitment term. Medication is prescribed only when a licensed clinician determines that it is medically appropriate. Final cost may vary based on the prescribed dosage and individualized treatment plan.

Enrollment does not guarantee that enclomiphene or any other medication will be prescribed.

What May Be Included

Care accessed through AlphaMD may include:

• Online health assessment
• Review of symptoms and medical history
• Review of qualifying laboratory results by a licensed clinician
• Individualized treatment recommendations from a licensed clinician
• Enclomiphene medication, if prescribed
• Ongoing clinical support
• Clinical review of follow-up laboratory results
• Clinician-directed dosage adjustments when medically appropriate
• Medication delivery from a qualified pharmacy where available

Treatment eligibility, included services, prescribing decisions, medication availability, and pharmacy access may vary based on clinical appropriateness, applicable law, and patient location.

How Enclomiphene Treatment Works

1. Complete Your Health Assessment

Provide information about your:

• Symptoms
• Medical history
• Current medications
• Previous hormone treatment
• Fertility goals

2. Complete or Submit Laboratory Testing

Laboratory testing helps determine whether low testosterone is present and whether enclomiphene may be clinically appropriate.

3. Meet With a Licensed Clinician

A licensed clinician reviews your results, discusses available treatment options, and determines whether treatment is appropriate.

4. Receive Prescribed Medication

If enclomiphene is prescribed, the medication may be prepared and shipped by a qualified pharmacy where legally available.

5. Complete Follow-Up Testing

The clinician overseeing your care may evaluate:

• Hormone levels
• Symptoms
• Treatment response
• Potential side effects

6. Adjust Treatment When Needed

The licensed clinician overseeing your care may maintain, increase, decrease, or discontinue your dosage based on your response and clinical results.

Why Choose AlphaMD?

Individualized Care

Your treatment plan is created by a licensed clinician based on:

• Symptoms
• Laboratory results
• Medical history
• Fertility goals
• Clinical needs

Convenient Telehealth Access

Complete your health assessment and attend eligible follow-up appointments remotely.

Ongoing Clinical Support

The licensed clinician overseeing your care monitors your progress and may adjust treatment when medically appropriate.

Transparent Pricing

Review available commitment options and program pricing before enrolling.

Convenient Medication Delivery

If medication is prescribed, it may be shipped directly from a qualified pharmacy where legally available.

Frequently Asked Questions

What is enclomiphene?

Enclomiphene is an oral SERM that may stimulate the body to release more LH and FSH. These hormones signal the testes to produce testosterone and support sperm production.

Is enclomiphene the same as clomiphene?

No. Clomiphene citrate contains two isomers:

• Enclomiphene
• Zuclomiphene

Enclomiphene is the trans isomer and is associated with clomiphene’s testosterone-stimulating activity.

Is enclomiphene a form of testosterone?

No. Enclomiphene does not contain testosterone. It may encourage the body to increase its own testosterone production.

Is enclomiphene FDA-approved?

Enclomiphene is not currently FDA-approved as a standalone medication.

Can enclomiphene increase testosterone?

Enclomiphene may increase total testosterone, LH, and FSH in eligible men with certain forms of secondary hypogonadism. Individual responses vary.

Does enclomiphene preserve fertility?

Enclomiphene may be less likely than traditional testosterone replacement therapy to suppress sperm production because it stimulates LH and FSH rather than replacing testosterone directly.

However, maintaining sperm production does not guarantee fertility or the ability to conceive. Men actively trying to conceive may need:

• Semen testing
• Additional laboratory testing
• Evaluation by a fertility specialist

Can I take enclomiphene with TRT?

A licensed clinician may use enclomiphene in specific hormone-treatment situations, but combining it with testosterone replacement therapy is not automatically appropriate.

External testosterone can suppress the same LH and FSH signals that enclomiphene is intended to stimulate. A licensed clinician will determine whether enclomiphene, testosterone replacement therapy, or another treatment is more appropriate.

Is enclomiphene better than TRT?

It depends on factors such as:

• The cause of low testosterone
• Laboratory results
• Medical history
• Fertility goals
• Treatment preferences

Enclomiphene may be considered when the testes can still produce testosterone and maintaining sperm production is important. Testosterone replacement therapy may be more appropriate when natural testosterone production cannot be sufficiently stimulated or when direct replacement is clinically indicated.

How quickly does enclomiphene work?

Hormone levels may begin changing during the first several weeks. Symptom improvement may take longer and is not guaranteed. Follow-up laboratory testing is needed to evaluate treatment response.

Will enclomiphene increase estrogen?

It can. As testosterone production increases, some testosterone may be converted into estradiol. The clinician overseeing your care may monitor estradiol when clinically appropriate.

Does enclomiphene shrink the testicles?

Enclomiphene is not expected to suppress LH and FSH in the same way as external testosterone. Because it stimulates the testes, it may be less likely to contribute to testicular shrinkage than testosterone replacement therapy.

Individual responses vary, and no treatment can guarantee preservation of testicular size or function.

Do I need laboratory testing?

Yes. Laboratory testing is needed to:

• Confirm low testosterone
• Evaluate its possible cause
• Establish baseline hormone levels
• Monitor treatment response

Can enclomiphene treat erectile dysfunction?

Enclomiphene is not a direct erectile dysfunction medication.

It may help some men when sexual symptoms are associated with low testosterone. Erectile dysfunction may also be related to:

• Cardiovascular disease
• Diabetes
• Medication effects
• Psychological factors
• Neurological conditions
• Other health issues

Can enclomiphene be used after stopping TRT?

A licensed clinician may consider it in certain situations after testosterone replacement therapy, particularly when restoring natural hormone production or sperm production is a goal.

The appropriate approach depends on:

• Treatment history
• Current hormone levels
• Testicular function
• Symptoms
• Fertility goals

Do I need to take enclomiphene forever?

Not necessarily. Treatment duration depends on the cause of low testosterone, treatment response, individual goals, and whether hormone levels remain adequate after treatment is discontinued.

Can I stop enclomiphene suddenly?

Do not change or stop treatment without speaking with the clinician overseeing your care. Testosterone levels may decrease after discontinuation if the underlying cause of low testosterone remains.

Find Out Whether Enclomiphene May Be Right for You

Low testosterone treatment is not one-size-fits-all.

A licensed clinician evaluates your:

• Symptoms
• Hormone levels
• Medical history
• Fertility goals
• Treatment preferences

These factors help determine whether enclomiphene may be medically appropriate.

Important Safety Information

• Enclomiphene is not FDA-approved as a standalone medication.
• Compounded medications are not reviewed by the FDA for safety, effectiveness, manufacturing quality, or dosing in the same manner as FDA-approved medications.
• Enclomiphene is available only by prescription when a licensed clinician determines that treatment is medically appropriate.
• Enrollment in an AlphaMD program does not guarantee a prescription.
• Prescribing decisions are made by the licensed clinician overseeing the patient’s care.
• Results vary, and treatment may not improve every symptom associated with low testosterone.

Tell the clinician overseeing your care about:

• All medical conditions
• Prescription and nonprescription medications
• Supplements
• Allergies
• Vision problems
• Fertility concerns
• Previous hormone treatments

Seek medical attention for severe or concerning symptoms.

The information on this page is educational and does not replace individualized medical advice, diagnosis, or treatment.