SERMORELIN ("Next Generation" Ipamorelin / CJC-1295)

$165.00 / 10 Weeks*

Intro and Pharmacokinetics

Sermorelin is a synthetic growth hormone-releasing hormone (GHRH) analogue that stimulates the pituitary gland to produce and release natural human growth hormone (HGH). It is primarily used for growth hormone deficiency (GHD) and as an anti-aging or performance-enhancing therapy due to its ability to promote muscle growth, fat loss, and improved recovery.

Pharmacokinetically, sermorelin is administered via subcutaneous injection, reaching peak plasma levels within 5–20 minutes and having a short half-life of approximately 10–20 minutes due to rapid enzymatic degradation. Despite its short half-life, it stimulates sustained HGH release by the pituitary for several hours. Sermorelin is metabolized primarily in the kidneys and liver, with inactive fragments excreted in the urine, making it a safer and more natural alternative to direct HGH administration.

Standard Dosing Guidelines

Typical Dose:

100–300 mcg per day, administered via subcutaneous injection, usually before bedtime to mimic natural growth hormone release.

Anti-Aging & General Wellness:

100–200 mcg per night (lower doses to promote gradual HGH optimization). Performance Enhancement / Fat Loss: 200–300 mcg per night, sometimes split into morning and evening doses for sustained stimulation.

Administration Notes

Best taken on an empty stomach before bedtime to enhance natural HGH pulsatility. Can be combined with GHRP peptides (e.g., GHRP-2 or GHRP-6) for stronger HGH release. Typical cycle duration: 3–6 months for noticeable effects on body composition, recovery, and well-being. Since sermorelin stimulates natural HGH production, its effects are gradual compared to direct HGH injections but offer a safer and more sustainable approach.

Side Effects

Sermorelin is generally well-tolerated, but some users may experience mild side effects, primarily due to its stimulation of growth hormone release. Side effects include:

Flushing

Mild Headaches

Dizziness or Lightheadedness

Nausea

Water Retention

Increased Hunger Fatigue or Drowsiness

Tingling or Numbness

Most side effects are mild and temporary, often improving as the body adjusts to the therapy. Proper dose titration and injection techniques can help minimize side effects, and those with pre-existing health conditions should consult a doctor before use.

In Short

Adding sermorelin to testosterone replacement therapy (TRT) can provide synergistic benefits by enhancing growth hormone (GH) production, which naturally declines with age. While TRT helps optimize testosterone levels, sermorelin stimulates the pituitary gland to increase natural HGH secretion, leading to improved fat loss, muscle growth, recovery, and overall vitality. This combination can enhance sleep quality, skin elasticity, cognitive function, and energy levels, promoting a more youthful and resilient physique. Additionally, sermorelin supports joint and connective tissue health, reducing the risk of injuries often associated with aging and intense training. Unlike direct HGH injections, sermorelin does not suppress natural GH production, making it a safer and more sustainable option for long-term use alongside TRT.