What Happens When You Stop Taking Sermorelin?

Published on July 24th, 2025

Sermorelin has gained popularity as a powerful tool in age management and hormone optimization, particularly for those looking to improve energy, sleep quality, metabolism, and lean muscle mass. As a growth hormone-releasing hormone (GHRH) analog, sermorelin stimulates the body’s natural production of growth hormone (GH) by activating the pituitary gland. But what happens when you stop taking sermorelin?

Before we answer that question, it’s important to understand sermorelin’s intended benefits and how it works. Unlike synthetic growth hormone injections that bypass the body’s regulatory systems, sermorelin encourages your body to produce its own GH—naturally and more safely. You can learn more about the full range of sermorelin benefits here.

The Transition Off Sermorelin

When a patient stops taking sermorelin, the effects don’t disappear overnight. Because sermorelin works by enhancing the body’s natural GH production, most patients will experience a gradual decline in GH levels rather than an abrupt crash. This tapering is generally well-tolerated, especially in patients who’ve used sermorelin long enough to improve pituitary responsiveness and overall hormone balance.

However, depending on individual health status, age, and lifestyle, the following changes are possible after discontinuation:

1. Reduced Energy and Stamina

As GH levels decline, you may start to feel more fatigued or notice a dip in endurance, particularly during physical activity. This is often one of the first signs patients report after stopping sermorelin.

2. Changes in Body Composition

Sermorelin supports lean muscle growth and fat metabolism. When GH stimulation decreases, it’s common to notice a gradual increase in body fat and possible loss of lean muscle mass if diet and exercise aren’t adjusted accordingly.

3. Sleep Disruptions

Many patients experience deeper, more restorative sleep while on sermorelin. After stopping, sleep quality may decline over time, especially if GH levels fall below optimal levels again.

4. Slower Recovery and Healing

Growth hormone plays a key role in cellular repair. Individuals who stop sermorelin may find that it takes longer to recover from workouts or minor injuries, especially as natural GH output diminishes with age.

5. Mood and Cognitive Effects

Some patients report a slight decline in mood or mental clarity after stopping therapy. This is likely due to the complex relationship between GH, neurotransmitters, and overall brain function. In fact, one study on growth hormone and cognitive function supports GH's role in attention and working memory, especially in aging populations.

Frequently Asked Questions (FAQs)

How long do sermorelin benefits last after stopping treatment?

For many individuals, benefits may taper gradually over a few weeks to a few months. The duration depends on treatment length, age, and whether healthy habits (exercise, sleep, diet) are maintained.

Is there a withdrawal period or rebound effect?

There is no known “withdrawal” in the traditional sense, as sermorelin does not suppress natural GH production the way synthetic GH might. However, some individuals may feel a noticeable decline in vitality as hormone levels adjust.

Can I restart sermorelin if symptoms return?

Yes. Sermorelin is often prescribed in cycles, and many providers allow patients to resume therapy if symptoms of low GH return and bloodwork supports the need.

Will my natural GH levels be lower than before treatment?

No, sermorelin stimulates your own GH production without shutting it down. After stopping, GH levels typically return to your original baseline, not below it.

Supporting Hormone Health After Discontinuation

If you decide to stop sermorelin—or need to for medical reasons—consider working with a knowledgeable provider to monitor your hormone levels and adjust your lifestyle accordingly. Some patients benefit from intermittent therapy cycles, while others explore additional options such as peptide combinations or supportive therapies to maintain results.

At AlphaMD, we take a personalized approach to hormone optimization. Whether you're starting therapy or considering a pause, our team is here to support your long-term health goals with expert care and evidence-based treatment strategies.