Does Sermorelin Need to Be Refrigerated? What Every Patient Should Know

Author: AlphaMD
Does Sermorelin Need to Be Refrigerated? What Every Patient Should Know

Sermorelin is a popular peptide therapy used to stimulate the body’s natural production of human growth hormone (HGH), offering benefits such as improved energy, better sleep, enhanced recovery, and more. If you're receiving sermorelin as part of your hormone therapy, a common question that arises is: does sermorelin need to be refrigerated? Understanding proper storage is key to maintaining the effectiveness of your treatment.

The Short Answer: Yes, Sermorelin Needs Refrigeration

Whether you’re using sermorelin acetate in injectable or reconstituted form, proper refrigeration is essential to preserve its potency. Like many peptide-based medications, sermorelin is temperature-sensitive. Storing it outside the recommended temperature range can degrade the peptide chain, reducing its therapeutic value.

Here’s what you need to know about sermorelin storage at home:

1. Before Reconstitution: Keep It Cool and Dry

If you’ve received sermorelin in its dry, lyophilized powder form:

  • Store it in the refrigerator, ideally between 36°F–46°F (2°C–8°C).
  • Avoid freezing.
  • Keep it away from heat, light, and humidity.

If your sermorelin is shipped to you unrefrigerated (which is common), don’t worry—it’s stable at room temperature for a short time during transit. Once you receive it, refrigerate it immediately.

2. After Reconstitution: Refrigeration Is Critical

Once mixed with bacteriostatic water or sterile saline:

  • The sermorelin solution must be kept refrigerated at all times (36°F–46°F).
  • It should be used within 30 days or as directed by your prescribing clinician.
  • Always inspect the solution for clarity—do not use if it appears cloudy or discolored.

3. Traveling With Sermorelin

If you’re traveling or on the go:

  • Use a cooler pack or insulated bag with ice packs to maintain the appropriate temperature.
  • Avoid leaving it in a hot car or exposing it to direct sunlight.
  • Consider planning injections around your travel to minimize time out of refrigeration.

Why This Matters: Potency and Safety

Incorrect storage can cause sermorelin to degrade, leading to:

  • Reduced effectiveness (less noticeable results over time)
  • Potential waste of medication
  • Interrupted progress in your treatment plan

AlphaMD patients receive guidance from licensed providers to ensure proper use and handling of all medications, including peptide therapies like sermorelin.

Final Thoughts

So, does sermorelin need to be refrigerated? Absolutely—both before and after it’s reconstituted. Proper storage ensures you get the full benefit of the therapy, without unnecessary risk or wasted doses.

If you’re unsure about how to store or mix your sermorelin, always consult your provider. Telehealth companies like AlphaMD are here to help make hormone therapy accessible, safe, and effective for both men and women through online consultations and direct-to-door delivery.

Have Questions?

Ask us about TRT, medical weightloss, ED, or other men's health topics.

Ask Now

People are asking...

If I accidentally left reconstituted hCG out of the fridge. How long is too long and I should be worried if at all?...

Generally this is fine depending on how long you plan to use it for. Some men don't even refrigerate their hCG because their dose is high enough that they'd go through it long before that would have a... See Full Answer

Do you offer peptides and if so can you talk a little bit about which ones you offer and the possible benefits?...

We do, though they are more tightly focused than a full on peptide provider. This is because we can only work with peptides that are available from pharmacies & approved for human consumption. Our mai... See Full Answer

Does pregnyl lose potency after 60 days?...

Technically yes, but realistically no. Most Pregnyl will come listed with a "60 day discard" date, as pharmacies are required to have 100% sterility & potency by that date per regulations. After that ... See Full Answer

Get $30 off your first month’s order

Enter your email address now to receive $30 off your first month’s cost, other discounts, and additional information about TRT.

Legal Disclaimer

This website is a repository of publicly available information and is not intended to form a physician-patient relationship with any individual. The content of this website is for informational purposes only. The information presented on this website is not intended to take the place of your personal physician's advice and is not intended to diagnose, treat, cure, or prevent any disease. Discuss this information with your own physician or healthcare provider to determine what is right for you. All information is intended for your general knowledge only and is not a substitute for medical advice or treatment for specific medical conditions. The information contained herein is presented in summary form only and intended to provide broad consumer understanding and knowledge. The information should not be considered complete and should not be used in place of a visit, phone or telemedicine call, consultation or advice of your physician or other healthcare provider. Only a qualified physician in your state can determine if you qualify for and should undertake treatment.