question from a user

If higher testosterone is causing changes to serotonergic pathways, could it be causing interactions with my SNRI medication?

AlphaMD's Answer

Testosterone increases serotonin signaling and is currently being studied as a treatment for depression.

As quoted in this article,

“The study has shown that testosterone increases the potential binding sites for commonly prescribed antidepressants such as SSRIs in the brain”

Basically testosterone makes medicines like SSRIs and SNRIs more effective, and may even mean patients can stop taking them once their testosterone levels become stable.

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