Hormonally speaking, it could relate to the neurosteroids pregnenolone and DHEA-S. These act directly on the brain and are associated with mood and cognition. When on exogenous testosterone, these hor... See Full Answer
I would first consider your current DHEA levels. There can be benefit as it can support test production/levels and in a different pathway. This can improve energy and libido. However, DEAH with TRT ca... See Full Answer
Adding DHEA benefits: Helps with the downstream effects of creation of DHEA-S and androstendione. Both of which typically have positive effects on mood and cognition. Adding DHEA risks: Extra DHEA can... See Full Answer
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
When men begin testosterone replacement therapy (TRT), the results can be transformative. Energy levels rise, muscle recovery improves, and motivation often comes roaring back. But sometimes, even after testosterone has been optimized, a handful of men still say something feels “off.”
Physically, they feel strong. Mentally, they’re sharp. Yet emotionally, it’s as if someone turned the color dial down—life feels a little flat.
This is where adding DHEA to the stack can make all the difference.
Dehydroepiandrosterone (DHEA) is a hormone naturally produced by the adrenal glands. While it’s not as well-known as testosterone, it serves as a building block for other hormones in the body. Think of it as part of the “behind-the-scenes” crew that helps keep your system balanced.
Over time, or under chronic stress, DHEA levels can decline. When this happens, men on TRT may still experience low mood, lack of motivation, or diminished libido despite otherwise solid results.
Pairing TRT with DHEA isn’t about piling on more hormones—it’s about creating balance. Here’s what men often notice when the stack is dialed in:
Think of testosterone as the foundation and DHEA as the finishing touch that rounds out the experience.
Hormones don’t work in isolation. When testosterone is optimized but adrenal hormones lag behind, men may be left wondering why they don’t feel as vibrant as they expected. Supporting both can provide a more complete return to balance—mind, body, and mood.
Of course, hormone therapy is never one-size-fits-all. Lab work, individualized dosing, and medical supervision are key.
At AlphaMD, we’ve seen firsthand how stacking TRT with DHEA can help men feel more like themselves again—not just stronger, but more alive. If you’re thriving physically but still searching for emotional balance, the TRT + DHEA stack may be the missing link.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
Hormonally speaking, it could relate to the neurosteroids pregnenolone and DHEA-S. These act directly on the brain and are associated with mood and cognition. When on exogenous testosterone, these hor... See Full Answer
I would first consider your current DHEA levels. There can be benefit as it can support test production/levels and in a different pathway. This can improve energy and libido. However, DEAH with TRT ca... See Full Answer
Adding DHEA benefits: Helps with the downstream effects of creation of DHEA-S and androstendione. Both of which typically have positive effects on mood and cognition. Adding DHEA risks: Extra DHEA can... See Full Answer
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