We've treated men at 700 before. Relative hypogonadism is far more rare than normal than traditional low Testosterone, but if you're suffering then you still deserve care. Also, you might look into Ti... See Full Answer
They are similar & there is something of a shared tolerance build up between them when switching between the two. However you can think of tirzepatide as the next gen of semaglutide - It's more effect... See Full Answer
Anyone will lose weight by adding a GLP-1RA like semaglutide or tirzepatide. They are the most popular drugs on the market and work well, regardless of the amount of weight someone needs to lose. The ... See Full Answer
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
Semaglutide has gained popularity for its effectiveness in weight loss and blood sugar control. However, one common side effect reported by many patients is fatigue. If you're feeling unusually tired while taking semaglutide, you're not alone — and the good news is, there are ways to manage it.
If you’re currently taking or considering semaglutide, semaglutide is part of AlphaMD’s featured treatments, delivered directly to your door and monitored through online consultations.
In this article, we’ll explore why semaglutide might cause fatigue, and practical strategies to help you feel more energized throughout your treatment journey.
Fatigue while using semaglutide is not uncommon and can result from several factors:
Semaglutide works in part by slowing gastric emptying and suppressing appetite. This can lead to a dramatic drop in how much you eat, especially in the early stages. Fewer calories can mean less energy — especially if you’re not meeting your body’s basic nutritional needs.
Semaglutide helps regulate blood sugar, which is beneficial for people with Type 2 diabetes or insulin resistance. However, sudden improvements in blood sugar — or rare episodes of low blood sugar (hypoglycemia) — can make you feel tired or lightheaded.
Some users experience nausea or diarrhea early in treatment, which can lead to dehydration. Even mild dehydration or loss of electrolytes like potassium and magnesium can cause fatigue, headaches, and weakness.
While weight loss is a desired outcome, shedding pounds too quickly can tax your body. Your metabolism may shift, your hormones may fluctuate, and your body needs time to adjust — all of which can leave you feeling drained.
The good news is that semaglutide-related fatigue is usually temporary and manageable. Here are effective strategies to help you combat it:
Even if your appetite is lower, aim to eat small meals rich in protein, fiber, healthy fats, and complex carbohydrates. Prioritize:
Avoid skipping meals, as this can make fatigue worse.
Aim for at least 8–10 glasses of water per day. Consider adding an electrolyte supplement if you’re experiencing nausea, diarrhea, or sweating more than usual. Coconut water or drinks with sodium, potassium, and magnesium can help restore balance.
Semaglutide can indirectly affect sleep due to digestive changes or low energy during the day. Practice good sleep hygiene by:
Even light activity like walking can improve your energy levels, mood, and digestion. Don’t push yourself too hard if you’re feeling exhausted, but avoid being sedentary for long stretches.
Fatigue can have multiple causes. Keep a log of:
This can help your healthcare provider make more personalized recommendations.
Sometimes, fatigue may signal that your dosage of semaglutide is increasing too quickly. A slower titration schedule or a temporary dosage adjustment may ease the side effects while still helping you achieve your weight loss goals.
If your fatigue is severe, persistent, or getting worse, it’s important to consult your healthcare provider. Fatigue could be related to another underlying condition such as thyroid dysfunction, anemia, or adrenal issues — which may require separate evaluation.
Fatigue while using semaglutide can be frustrating, but in most cases, it can be managed with proper nutrition, hydration, rest, and monitoring. Your body is adjusting to a powerful new medication and a major metabolic shift.
At AlphaMD, we support patients with personalized telehealth guidance and prescription delivery to ensure you're never navigating your health journey alone. If you're considering semaglutide or currently experiencing side effects, our expert providers are here to help you stay on track and feel your best.
Ready to explore safe and effective weight loss options? Visit AlphaMD.org to schedule your consultation today.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
We've treated men at 700 before. Relative hypogonadism is far more rare than normal than traditional low Testosterone, but if you're suffering then you still deserve care. Also, you might look into Ti... See Full Answer
They are similar & there is something of a shared tolerance build up between them when switching between the two. However you can think of tirzepatide as the next gen of semaglutide - It's more effect... See Full Answer
Anyone will lose weight by adding a GLP-1RA like semaglutide or tirzepatide. They are the most popular drugs on the market and work well, regardless of the amount of weight someone needs to lose. The ... See Full Answer
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