How Many IU of HCG Per Week Is Right for You?

If you're considering or currently undergoing testosterone replacement therapy (TRT), you may have come across the recommendation to include human chorionic gonadotropin (HCG) as part of your protocol. One of the most common questions we hear from patients is, “How many IU of HCG per week should I take?” The answer depends on your individual goals, your body's response to TRT, and the guidance of a knowledgeable medical provider.

HCG is often prescribed to maintain testicular function, support fertility, and help preserve natural testosterone production in men undergoing TRT. It mimics the action of luteinizing hormone (LH), which stimulates the testes to produce testosterone and sperm. This can help prevent testicular atrophy and support hormonal balance. For a full overview of HCG benefits, including how it fits into a comprehensive TRT protocol, see our in-depth guide.

Typical Dosage Ranges

When it comes to how many IU of HCG per week is appropriate, most TRT clinics—based on decades of clinical experience—prescribe somewhere between 500 IU to 2,000 IU per week, usually divided into multiple doses. A common protocol is 250 IU every other day or 500 IU two to three times per week. Some patients may require higher doses depending on their fertility goals, age, or lab results.

It’s important to note that more is not always better. Excessively high doses of HCG can lead to elevated estrogen levels, mood swings, and even desensitization of the Leydig cells in the testes over time. For that reason, ongoing monitoring through blood work is essential. Your provider may adjust your dosage based on how your body is responding, including your testosterone levels, testicular size, energy levels, and fertility markers such as sperm count.

When to Use HCG with TRT

Not every patient on TRT needs HCG, but many benefit from it—especially men who want to maintain fertility or prevent testicular shrinkage. HCG can also help some men feel more “natural” on TRT by preserving some of the body's own hormone production. That said, it should always be used under medical supervision. Self-administering HCG without proper dosing and lab monitoring can do more harm than good.

The Bottom Line

So, how many IU of HCG per week is right for you? The answer isn’t one-size-fits-all. A typical range falls between 500 and 2,000 IU per week, administered in divided doses, but finding the optimal amount depends on your goals and your body's response. At AlphaMD, our medical team customizes every TRT and HCG protocol to fit the individual needs of our patients. If you're ready to take the next step in optimizing your hormone health, schedule a consultation today—we’re here to help guide you with clarity, experience, and care.