The most common case is when a patient insists on it because they've read about the medication and really want to take a pill instead of do an injection. The second most common instance is when a man... See Full Answer
The arguments against long term use of Clomid: There are no good long-term studies on its use. There is only 1 study on its use for up to 3 years, and it showed that many men in that study had to drop... See Full Answer
You are right in that Clomid provides better fertility than hCG because it also increases FSH, which we now know matters less for sperm count, and more for sperm quality (motility and morphology). New... See Full Answer
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
Post Cycle Therapy (PCT) is a crucial part of any testosterone-related treatment plan, especially for individuals who’ve completed a cycle of anabolic steroids or undergone testosterone replacement therapy (TRT). Testosterone replacement therapy can support patients experiencing low testosterone symptoms, but restoring natural hormone production afterward may require a different approach—this is where Clomid (Clomiphene Citrate) comes into play.
In this article, we’ll explore how Clomid is used for PCT, why it works, and who might benefit from it.
Clomid, also known by its generic name Clomiphene Citrate, is a selective estrogen receptor modulator (SERM) most commonly prescribed to treat infertility in women. However, it also has a well-documented off-label use in men: stimulating natural testosterone production after exogenous testosterone has suppressed it.
During TRT or anabolic steroid cycles, your body’s natural testosterone production slows down or stops due to the external supply of hormones. Once the cycle ends, your body needs a push to restart natural testosterone production. That’s where Clomid can help.
Clomid works by blocking estrogen receptors in the brain, specifically in the hypothalamus. This “tricks” the brain into thinking estrogen levels are lower than they actually are, which causes the hypothalamus to release more gonadotropin-releasing hormone (GnRH). In turn, this stimulates the pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH)—both critical for signaling the testes to produce testosterone.
In other words, Clomid helps restart the hormonal feedback loop that’s often suppressed during TRT or steroid use.
Clomid is typically introduced after completing a testosterone or steroid cycle, once the body is no longer receiving exogenous testosterone. The timing and dosage can vary based on factors like:
In many PCT protocols, Clomid is used for 2–4 weeks at daily doses ranging from 25mg to 50mg, although this should always be guided by lab work and medical advice.
While Clomid is generally well-tolerated, some patients may experience:
It’s also worth noting that Clomid doesn’t work for everyone, and overuse or misuse may lead to hormonal imbalances or prolonged suppression.
That’s why Clomid should only be used under medical supervision, with regular blood work to monitor your hormonal levels and adjust treatment accordingly.
Clomid can be effective for:
Clomid plays a vital role in many PCT protocols by helping the body reboot its natural testosterone production. It’s not a one-size-fits-all solution, and it’s most effective when part of a personalized treatment plan that includes lab testing and follow-up.
At AlphaMD, we provide science-backed, physician-led care for both men and women seeking hormone optimization. If you're considering TRT or looking for guidance on post-cycle recovery, our team can help you explore your options safely and effectively.
Start your personalized hormone journey today at AlphaMD.org.
At AlphaMD, we're here to help. Feel free to ask us any question you would like about TRT, medical weightloss, ED, or other topics related to men's health. Or take a moment to browse through our past questions.
The most common case is when a patient insists on it because they've read about the medication and really want to take a pill instead of do an injection. The second most common instance is when a man... See Full Answer
The arguments against long term use of Clomid: There are no good long-term studies on its use. There is only 1 study on its use for up to 3 years, and it showed that many men in that study had to drop... See Full Answer
You are right in that Clomid provides better fertility than hCG because it also increases FSH, which we now know matters less for sperm count, and more for sperm quality (motility and morphology). New... See Full Answer
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