A New Oral Option for Testosterone Replacement: What Patients Should Know

Testosterone Replacement Therapy (TRT) has long been a cornerstone treatment for individuals experiencing low testosterone levels due to medical conditions such as hypogonadism. Traditionally, TRT has been administered via injections, gels, or patches—each with their own pros and cons. But now, there’s growing interest in oral testosterone therapies, which are reshaping the way patients and providers approach hormone replacement.

According to a recent article from Cleveland Clinic, new FDA-approved oral testosterone medications are offering a convenient and effective alternative to more traditional treatment methods.

What Is Oral Testosterone Therapy?

Oral TRT involves taking testosterone in pill or capsule form. One of the newest medications, Kyzatrex, is a softgel capsule that uses testosterone undecanoate—a form of testosterone designed to be absorbed through the lymphatic system rather than the liver, reducing the risk of liver toxicity seen in older oral formulations.

These therapies are approved for individuals with hypogonadism due to medical causes, such as pituitary disorders or testicular failure—not for age-related declines in testosterone.

Benefits of Oral TRT

The appeal of oral testosterone therapy lies largely in its convenience and simplicity:

• No injections or skin applications required
• Discreet and easy to take
• Can be taken with meals—Kyzatrex does not require a high-fat meal, making dosing more flexible
• Stable testosterone levels with consistent dosing

For many patients, these advantages can improve adherence to treatment, making it easier to maintain healthy testosterone levels over time.

What Are the Risks?

Like all forms of TRT, oral testosterone therapy is not without potential side effects. These may include:

• Elevated blood pressure
• Increased red blood cell count (polycythemia)
• Liver function changes (though less likely with newer oral forms)
• Mood or libido changes
• Fluid retention

Because of these risks, regular monitoring through lab work and blood pressure checks is essential. According to the FDA, while TRT does not appear to increase cardiovascular risk in medically eligible patients, it should always be used under medical supervision.

Is Oral Testosterone Right for You?

Oral TRT may be a good option if you:

• Have been diagnosed with hypogonadism by a healthcare provider
• Prefer not to use injections, gels, or patches
• Are looking for a more convenient method to maintain hormone balance

However, not every patient is a candidate. A thorough consultation and hormone panel are needed to determine the best and safest treatment approach. Importantly, oral TRT is not recommended for those experiencing low testosterone solely due to aging.

Final Thoughts from AlphaMD

At AlphaMD, we’re committed to making hormone health more accessible, evidence-based, and patient-centered. As a fully online telehealth provider, we offer personalized care, convenient consultations, and direct-to-door medication delivery for approved TRT patients.

As new therapies like oral testosterone capsules emerge, we continue to evolve alongside the science—helping patients make informed decisions with the support of licensed medical professionals.

To learn more about new treatment options, visit the full Cleveland Clinic article here.

This article is for educational purposes only and should not be taken as medical advice. Always consult with a licensed healthcare provider before starting or changing any treatment plan.